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Energy metabolism; Nervous system support; Methylation support; Homocysteine metabolism
Adults with busy schedules who want daily energy metabolism support and people seeking methylation-focused B vitamins in active forms.
Take 1 capsule 1 to 2 times daily with meals; taking with food may improve comfort for high-potency B vitamins and may reduce niacin-related flushing.
Certified Gluten-Free; Non-GMO; Hypoallergenic
Methylcobalamin acts as a cofactor in methylation and energy metabolism, supporting red blood cell formation and normal nerve function.
Caution: High-potency B12 is generally well tolerated; those with B12-sensitive lab tests should know supplementation may affect blood levels.
Niacin participates in cellular energy production by forming NAD/NADP, which are required for hundreds of redox reactions.
Caution: High amounts may cause flushing or digestive discomfort; take with food and avoid combining with other high-niacin products unless advised.
Thiamin serves as a coenzyme in carbohydrate metabolism, helping convert food into cellular energy and supporting nervous system function.
Caution: Very high doses are usually well tolerated but may cause mild stomach upset in some people; take with meals if sensitive.
L-5-MTHF is the active folate form used in methylation reactions that support homocysteine metabolism and neurotransmitter synthesis.
Caution: Folate can mask signs of low vitamin B12 on some lab tests; consistent B12 intake is important.
Vitamin B6-dependent enzymes help form neurotransmitters and support amino acid metabolism and glycogen breakdown for energy.
Caution: Excessive long-term B6 intake may cause numbness or tingling; avoid combining with other high-dose B6 supplements.
This formula pairs active methyl donors (L-5-MTHF and methylcobalamin) to support methylation, while B6 helps convert amino acids into neurotransmitters. Thiamin and niacin supply core coenzymes for carbohydrate and cellular energy metabolism, complementing the methylation-focused nutrients.
Label Warning: If you are pregnant or lactating, have any health condition, or are taking any medication, consult a health professional before use. Natural color variation may occur.
Who should be cautious: People with a known sensitivity to B vitamins or niacin flush may wish to start with a lower dose and take with food. Those with kidney concerns or on restricted potassium or phosphate diets may wish to review B-complex use with a healthcare provider. People on medications should consult a healthcare provider before use.
Storage: Store in a cool, dry place.
Helps address mild memory problems associated with normal age-related cognitive decline.
Promotes healthy methylation, a process that maintains healthy gene expression, neurotransmitter production and homocysteine metabolism. Methylation plays important roles in cardiovascular health, neurocognitive health and emotional wellness.
As a dietary supplement, take 1 capsule, 1-2 times daily, with meals.
Natural color variation can occur. Product can range from light yellow to bright yellow.
Store in a cool, dry place.
If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.
Keep out of the reach of children. Use only if safety seal is intact.
Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity.
While iHerb strives to ensure the accuracy of its product images and information, some manufacturing changes to packaging and/or ingredients may be pending update on our site. Although items may occasionally ship with alternate packaging, freshness is always guaranteed. We recommend that you read labels, warnings and directions of all products before use and not rely solely on the information provided by iHerb.
| Supplement facts | ||
| Serving Size: 1 Capsule | ||
| Servings Per Container: 60 | ||
| Amount Per Serving | %DV | |
| Thiamin (as thiamin HCl) (B1) | 100 mg | 8,333% |
| Riboflavin (as vitamin B2 and 60% riboflavin 5' phosphate (activated B2)) | 12.7 mg | 977% |
| Niacin (as niacinamide and 8% inositol hexaniacinate (no-flush niacin)) | 108 mg | 675% |
| Vitamin B6 (as pyridoxine HCl and 40% pyridoxal 5' phosphate (activated B6)) | 16.7 mg | 982% |
| Folate (as Metafolin®, L-5-MTHF) | 667 mcg DFE (400 mcg L5-MTHF) | 167% |
| Vitamin B12 (as methylcobalamin) | 400 mcg | 16,667% |
| Biotin | 400 mcg | 1,333% |
| Pantothenic acid (as calcium pantothenate) (B5) | 100 mg | 2,000% |
| %Daily value (DV) | ||
Vegetarian capsule (cellulose, water), ascorbyl palmitate.
